Resident stromal cell-derived MMP-9 promotes the growth of colorectal metastases in the liver microenvironment.

Abstract

Colorectal cancer, the second leading cause of cancer deaths in the United States, has a high probability of metastasizing to the liver. Matrix metalloproteinases (MMPs) are a family of zinc dependent endopeptidases that are implicated in cancer metastasis and many aspects of tumor progression. Using a splenic injection experimental metastasis model, mice… (More)

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