Resident microglia, and not peripheral macrophages, are the main source of brain tumor mononuclear cells.

@article{Mueller2015ResidentMA,
  title={Resident microglia, and not peripheral macrophages, are the main source of brain tumor mononuclear cells.},
  author={Annett Mueller and Susan Brandenburg and Kati Turkowski and Susanne Mueller and Peter Vajkoczy},
  journal={International journal of cancer},
  year={2015},
  volume={137 2},
  pages={278-88}
}
Gliomas consist of multiple cell types, including an abundant number of microglia and macrophages, whereby their impact on tumor progression is controversially discussed. To understand their unique functions and consequently manipulate either microglia or macrophages in therapeutic approaches, it is essential to discriminate between both cell populations. Because of the lack of specific markers, generally total body irradiated chimeras with labeled bone marrow cells were used to identify… CONTINUE READING
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