Resident lung antigen-presenting cells have the capacity to promote Th2 T cell differentiation in situ.

@article{Constant2002ResidentLA,
  title={Resident lung antigen-presenting cells have the capacity to promote Th2 T cell differentiation in situ.},
  author={Stephanie L. Constant and Jennifer L. Brogdon and Damani Piggott and Christina A. Herrick and Irene P Visintin and Nancy H. Ruddle and Kim Bottomly},
  journal={The Journal of clinical investigation},
  year={2002},
  volume={110 10},
  pages={1441-8}
}
Antigen exposure via airway epithelia is often associated with a failure to prime or with the preferential priming of Th2 cells. We previously reported that the intranasal delivery of a Th1-inducing antigen promoted Th2-dominated responses, rather than the expected Th1 responses. Thus, we proposed that when pulmonary T cell priming is induced, the lung microenvironment might intrinsically favor the generation of Th2 types of responses. To establish a potential mechanism for such preferential… CONTINUE READING

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