Resident alveolar macrophages suppress, whereas recruited monocytes promote, allergic lung inflammation in murine models of asthma.

@article{Zasona2014ResidentAM,
  title={Resident alveolar macrophages suppress, whereas recruited monocytes promote, allergic lung inflammation in murine models of asthma.},
  author={Zbigniew Zasłona and Sally A. Przybranowski and Carol A. Wilke and Nico Van Rooijen and Seagal Teitz-Tennenbaum and John J. Osterholzer and John Erby Wilkinson and Bethany B Moore and Marc Peters-Golden},
  journal={Journal of immunology},
  year={2014},
  volume={193 8},
  pages={4245-53}
}
The role and origin of alveolar macrophages (AMs) in asthma are incompletely defined. We sought to clarify these issues in the context of acute allergic lung inflammation using house dust mite and OVA murine models. Use of liposomal clodronate to deplete resident AMs (rAMs) resulted in increased levels of inflammatory cytokines and eosinophil numbers in lavage fluid and augmented the histopathologic evidence of lung inflammation, suggesting a suppressive role for rAMs. Lung digests of asthmatic… CONTINUE READING
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