Resident CD4+ alpha beta T cells of the murine female genital tract: a phenotypically distinct T cell lineage that rapidly proliferates in response to systemic T cell activation stimuli.

@article{Ibraghimov1995ResidentCA,
  title={Resident CD4+ alpha beta T cells of the murine female genital tract: a phenotypically distinct T cell lineage that rapidly proliferates in response to systemic T cell activation stimuli.},
  author={Alexander R. Ibraghimov and Randy E Sacco and M{\'a}ty{\'a}s S{\'a}ndor and L Z Iakoubov and Richard G. Lynch},
  journal={International immunology},
  year={1995},
  volume={7 11},
  pages={1763-9}
}
A population of CD4+ cells has been identified in the murine female genital tract (FGT). Phenotypic studies of FGT CD4+ cells demonstrate that they express CD3 and that the majority of these cells are alpha beta TCR+Thy-1+. Most of the Thy-1+CD4+alpha beta TCR+ cells resemble memory T cells based on their expression of CD44, L-selectin and CD45RB antigens. The vast majority of Thy-1+CD4+alpha beta TCR+ FGT cells are CD5+ and all of them are B220-. Systemic stimuli including infection with… CONTINUE READING

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