Reshaping human antibodies for therapy
@article{Riechmann1988ReshapingHA, title={Reshaping human antibodies for therapy}, author={Lutz Riechmann and Michael Ronald Clark and Herman Waldmann and Gregory Paul Winter}, journal={Nature}, year={1988}, volume={332}, pages={323-327} }
A human IgGI antibody has been reshaped for serotherapy in humans by introducing the six hypervariable regions from the heavy- and light-chain variable domains of a rat antibody directed against human lymphocytes. The reshaped human antibody is as effective as the rat antibody in complement and is more effective in cell-mediated lysis of human lymphocytes.
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Methods and systems for the determination of antigen specific antibodies of a par ticular immunoglobulin class and for the identification of a patient who is at risk of developing an adverse drug reaction (ADR) during treatment with a TmAB are outlined.
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A reshaped human antibody with the same specificity was constructed by genetic engineering and it is believed that this antibody will be a potent immunosuppressant as well as being useful as a component of therapy for lymphoid malignancies.
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