Reshaping human antibodies for therapy

@article{Riechmann1988ReshapingHA,
  title={Reshaping human antibodies for therapy},
  author={Lutz Riechmann and Michael Ronald Clark and Herman Waldmann and Gregory Paul Winter},
  journal={Nature},
  year={1988},
  volume={332},
  pages={323-327}
}
A human IgGI antibody has been reshaped for serotherapy in humans by introducing the six hypervariable regions from the heavy- and light-chain variable domains of a rat antibody directed against human lymphocytes. The reshaped human antibody is as effective as the rat antibody in complement and is more effective in cell-mediated lysis of human lymphocytes. 
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