Reshaping a human antibody to inhibit the interleukin 6-dependent tumor cell growth.

  title={Reshaping a human antibody to inhibit the interleukin 6-dependent tumor cell growth.},
  author={Kenichi Sato and Masayuki Tsuchiya and John Saldanha and Yasuo Koishihara and Yoshiyuki Ohsugi and Toshimitsu Kishimoto and Mary M. Bendig},
  journal={Cancer research},
  volume={53 4},
The mouse PM-1 monoclonal antibody binds to the human interleukin 6 receptor, inhibits IL-6 functions, and shows strong antitumor cell activity against multiple myeloma cells. In order to be effective as a therapeutic agent administered to human patients in repeated doses, reshaped human PM-1 antibodies consisting of human REI-based light chain and NEW-based heavy chain variable regions were designed and constructed with the assistance of a structural model of the mouse PM-1 variable regions… CONTINUE READING


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