Resetting the histone code at CDKN2A in HNSCC by inhibition of DNA methylation

  title={Resetting the histone code at CDKN2A in HNSCC by inhibition of DNA methylation},
  author={Madelene M Coombes and Katrina L Briggs and James R. Bone and Gary L Clayman and A El-naggar and Sharon Y. R. Dent},
Head and neck squamous cell carcinoma (HNSCC) is the fifth most frequent cancer in the US. Several genetic and epigenetic alterations are associated with HNSCC tumorigenesis, including inactivation of CDKN2A, which encodes the p16 tumor suppressor, in cell lines and primary tumors by DNA methylation. Reactivation of tumor suppressor genes by DNA-demethylating agents and histone deacetylase (HDAC) inhibitors shows therapeutic promise for other cancers. Therefore, we investigated the ability of… CONTINUE READING


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