Resetting the biological clock: mediation of nocturnal CREB phosphorylation via light, glutamate, and nitric oxide.

@article{Ding1997ResettingTB,
  title={Resetting the biological clock: mediation of nocturnal CREB phosphorylation via light, glutamate, and nitric oxide.},
  author={Jian. M. Ding and Lia E. Faiman and William J Hurst and Liana Kuriashkina and Martha L U Gillette},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={1997},
  volume={17 2},
  pages={667-75}
}
Synchronization between the environmental lighting cycle and the biological clock in the suprachiasmatic nucleus (SCN) is correlated with phosphorylation of the Ca2+/cAMP response element binding protein (CREB) at the transcriptional activating site Ser133. Mechanisms mediating the formation of phospho-CREB (P-CREB) and their relation to clock resetting are unknown. To address these issues, we probed the signaling pathway between light and P-CREB. Nocturnal light rapidly and transiently induced… CONTINUE READING