Resetting central and peripheral circadian oscillators in transgenic rats.

@article{Yamazaki2000ResettingCA,
  title={Resetting central and peripheral circadian oscillators in transgenic rats.},
  author={Shin Yamazaki and Rika Numano and Michikazu Abe and Akiko Hida and Ri‐ichi Takahashi and Masatsugu Ueda and Gene D. Block and Yoshiyuki Sakaki and Michael Menaker and Hajime Tei},
  journal={Science},
  year={2000},
  volume={288 5466},
  pages={
          682-5
        }
}
In multicellular organisms, circadian oscillators are organized into multitissue systems which function as biological clocks that regulate the activities of the organism in relation to environmental cycles and provide an internal temporal framework. To investigate the organization of a mammalian circadian system, we constructed a transgenic rat line in which luciferase is rhythmically expressed under the control of the mouse Per1 promoter. Light emission from cultured suprachiasmatic nuclei… 

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TLDR
This overview examines landmark studies in the history of the study of circadian timing system, and highlights the current understanding of the operation of circadian clocks with a focus on topics of interest to the neuroscience community.

The mammalian circadian system: a hierarchical multi-oscillator structure for generating circadian rhythm

  • S. Honma
  • Biology
    The Journal of Physiological Sciences
  • 2018
TLDR
The oscillatory coupling within and between the regional oscillators appears to be critical for the extraordinary stability and the wide range of adaptability of the circadian clock, the mechanism of which is now being elucidated with newly advanced molecular tools.

Monitoring cell-autonomous circadian clock rhythms of gene expression using luciferase bioluminescence reporters.

TLDR
A stable transduction protocol using lentivirus-mediated gene delivery and lentiviral vector system is described, superior to traditional methods such as transient transfection and germline transmission because of its efficiency and versatility.

Peripheral Circadian Oscillators

TLDR
The discovery of the genes that constituted the molecular timekeeping system provided the tools for demonstrating the existence of bona fide circadian oscillators in nearly every peripheral tissue in animals, including rodents, in the late 1990s and early 2000s, which led to the current understanding that the circadian system in animals is a hierarchical multi-oscillatory network, composed of master pacemaker(s) in the brain and oscillator in peripheral organs.
...

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