Resetting cancer stem cell regulatory nodes upon MYC inhibition.

Abstract

MYC deregulation is common in human cancer and has a role in sustaining the aggressive cancer stem cell populations. MYC mediates a broad transcriptional response controlling normal biological programmes, but its activity is not clearly understood. We address MYC function in cancer stem cells through the inducible expression of Omomyc-a MYC-derived… (More)

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@article{Galardi2016ResettingCS, title={Resetting cancer stem cell regulatory nodes upon MYC inhibition.}, author={Silvia Galardi and Mauro Savino and Fiorella Scagnoli and Serena Pellegatta and Federica Pisati and Federico Zambelli and Barbara Illi and Daniela Annibali and Sara Beji and Elisa Orecchini and Maria Adele Alberelli and Clara Apicella and Rosaria Anna Fontanella and Alessandro Michienzi and Gaetano Finocchiaro and Maria Giulia Farace and Giulio Pavesi and Silvia Anna Ciafr{\'e} and Sergio Nasi}, journal={EMBO reports}, year={2016}, volume={17 12}, pages={1872-1889} }