Reservoir function of the stratum corneum: development of an in vivo method to quantitatively determine the stratum corneum reservoir for topically applied substances.

@article{Teichmann2005ReservoirFO,
  title={Reservoir function of the stratum corneum: development of an in vivo method to quantitatively determine the stratum corneum reservoir for topically applied substances.},
  author={Alexa Teichmann and Ute Jacobi and H J Weigmann and Wolfram Sterry and Juergen Lademann},
  journal={Skin pharmacology and physiology},
  year={2005},
  volume={18 2},
  pages={75-80}
}
Investigations on the stratum corneum (SC) reservoir for topically applied substances are of importance in dermatologic science in order to assess the pharmacokinetics of these substances. In the present study, an in vivo method was developed to determine the SC reservoir quantitatively and to investigate the temporal behavior of this reservoir. Therefore, increasing amounts of an oil-in-water emulsion (o/w emulsion) containing 4% of a chemical UV filter were topically applied onto the flexor… CONTINUE READING