Resequencing studies of nonmodel organisms using closely related reference genomes: optimal experimental designs and bioinformatics approaches for population genomics.

@article{Nevado2014ResequencingSO,
  title={Resequencing studies of nonmodel organisms using closely related reference genomes: optimal experimental designs and bioinformatics approaches for population genomics.},
  author={Bruno Nevado and Sebasti{\'a}n Ramos-Onsins and Miguel P{\'e}rez-Enciso},
  journal={Molecular ecology},
  year={2014},
  volume={23 7},
  pages={1764-79}
}
Decreasing costs of next-generation sequencing (NGS) experiments have made a wide range of genomic questions open for study with nonmodel organisms. However, experimental designs and analysis of NGS data from less well-known species are challenging because of the lack of genomic resources. In this work, we investigate the performance of alternative experimental designs and bioinformatics approaches in estimating variability and neutrality tests based on the site-frequency-spectrum (SFS) from… CONTINUE READING
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