Resequencing and mutational analysis using oligonucleotide microarrays

  title={Resequencing and mutational analysis using oligonucleotide microarrays},
  author={Joseph G. Hacia},
  journal={Nature Genetics},
  volume={21 Suppl 1},
Oligonucleotide microarray (DNA chip)–based hybridization analysis is a promising new technology which potentially allows rapid and cost–effective screens for all possible mutations and sequence variations in genomic DNA. Here, I review current strategies and uses for DNA chip–based resequencing and mutational analysis, the underlying principles of experimental designs, and future efforts to improve the sensitivity and specificity of chip–based assays. 

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