Resemblance of osteophytes in experimental osteoarthritis to transforming growth factor beta-induced osteophytes: limited role of bone morphogenetic protein in early osteoarthritic osteophyte formation.

@article{Davidson2007ResemblanceOO,
  title={Resemblance of osteophytes in experimental osteoarthritis to transforming growth factor beta-induced osteophytes: limited role of bone morphogenetic protein in early osteoarthritic osteophyte formation.},
  author={Esmeralda N. Blaney Davidson and Elly L. Vitters and Henk M. van Beuningen and Fons A J van de Loo and Wim B. van den Berg and Peter M van der Kraan},
  journal={Arthritis and rheumatism},
  year={2007},
  volume={56 12},
  pages={4065-73}
}
OBJECTIVE Osteoarthritis (OA) is characterized by cartilage damage, synovial fibrosis, and osteophyte formation. Both transforming growth factor beta (TGFbeta) and bone morphogenetic protein 2 (BMP-2) can induce the formation of osteophytes during OA, but their specific role in this process is unclear. The purpose of this study was to investigate the respective contributions of TGFbeta and BMP-2 to OA. METHODS Mouse knee joints injected with adenovirus (Ad-TGFbeta or Ad-BMP-2) were compared… CONTINUE READING