Resective Pediatric Epilepsy Surgery in Lennox-Gastaut Syndrome

@article{Lee2010ResectivePE,
  title={Resective Pediatric Epilepsy Surgery in Lennox-Gastaut Syndrome},
  author={Yun Jin Lee and Hoon-Chul Kang and Joon Soo Lee and Shin Hye Kim and Dong-Seok Kim and Kyu-Won Shim and Yun-Ho Lee and Tae Seung Kim and Heung Dong Kim},
  journal={Pediatrics},
  year={2010},
  volume={125},
  pages={e58 - e66}
}
  • Yun Jin Lee, Hoon-Chul Kang, +6 authors Heung Dong Kim
  • Published 2010
  • Medicine
  • Pediatrics
OBJECTIVE: The objective of this study was to evaluate the role of resective pediatric epilepsy surgery for Lennox-Gastaut syndrome (LGS). METHODS: We analyzed clinical data of 27 children and adolescents who had LGS and underwent resective epilepsy surgery despite abundant (>30% of preoperative interictal and/or ictal epileptiform discharges) generalized or generalized contralateral maximal and multiregional electroencephalogram abnormalities. RESULTS: On high-resolution MRI, cerebral lesions… Expand
Long-term Outcome of Resective Epilepsy Surgery in Patients With Lennox-Gastaut Syndrome
TLDR
Resective surgery is a viable option in some patients to treat seizures that are associated with Lennox-Gastaut syndrome, with a high probability of seizure control and better adaptive function. Expand
Surgical Treatment of Patients with Lennox-Gastaut Syndrome Phenotype
TLDR
The data suggest that resective epilepsy surgery can be successful in patients with LGS phenotype as long as the EEG shows dominance of discharges in one hemisphere and corresponding ipsilateral imaging findings, even with contralateral ictal discharges. Expand
Lennox-Gastaut syndrome symptomatic to hypothalamic hamartoma: evolution and long-term outcome following surgery.
TLDR
Patients with Lennox-Gastaut syndrome symptomatic to hypothalamic hamartomas have better postsurgical outcome due to other etiologies compared with cryptogenic and symptomatic Lennox’s Gastaut syndrome patients, however, compared with overall hypothalamicHamartomas postsurgical outcomes, this cohort was less favorable. Expand
Outcomes of epilepsy surgery in childhood-onset epileptic encephalopathy
TLDR
Evaluated outcomes and role of epilepsy surgery in children with intractable epileptic encephalopathy showed more significant intellectual improvement correlated well with shorter epilepsy duration, good seizure outcomes, and decreased number of antiepileptic drugs. Expand
Long-term prognosis of patients with Lennox–Gastaut syndrome in recent decades
TLDR
KD and epilepsy surgery were effective for seizure control, but they did not necessarily lead to the maintenance of a seizure-free state, and LGS remains a form of intractable epilepsy despite the application of recent advanced treatment modalities. Expand
Reversible Lennox-Gastaut Syndrome: an Exemplary Case of CurativeFocal Heterotopia Resection
TLDR
This is an instructive case of curative focal subcortical heterotopia resection in a six-year-old boy with refractory, symptomatic generalized epilepsy who fit criteria for Lennox-Gastaut syndrome who had normalization of his EEG, resolution of behavioral problems and developmental delay, and no seizure recurrence off all antiepileptic medications. Expand
Resective surgery combined with corpus callosotomy for children with non-focal lesional Lennox–Gastaut syndrome
TLDR
Resective surgery combined with CCT can provide favorable seizure control and obvious improvements in QOL and IQ in children with LGS. Expand
Anterior corpus callosotomy in school-aged children with Lennox-Gastaut syndrome: a prospective study.
TLDR
Anterior CCT is a promising treatment for school-aged children with LGS, and can present marked seizure control and improvement in QOL and IQ, all of which were significantly better than the effects of treatment with multiple AEDs. Expand
Epilepsy Surgery is a Viable Treatment for Lennox Gastaut Syndrome.
TLDR
Current surgical treatment options for patients with Lennox Gastaut Syndrome are reviewed, including: focal cortical resection, vagus nerve stimulation and corpus callosotomy, as well as the concept of LGS as a secondary network disorder. Expand
Surgical options for patients with Lennox‐Gastaut syndrome
TLDR
For patients with treatment resistance to other modalities for Lennox‐Gastaut syndrome, a further option is surgical intervention, with promising results, with a high percentage of patients having improved seizure control. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 30 REFERENCES
Pediatric intractable epilepsy syndromes: Reason for early surgical intervention
TLDR
Early surgical intervention in pediatric intractable epilepsy syndromes may results in a favorable outcome in a high percentage of cases and may provides an important opportunity to prevent irreversible decline in intelligence and disability. Expand
Successful surgery for epilepsy due to early brain lesions despite generalized EEG findings
TLDR
Epilepsy surgery may be successful for selected children and adolescents with a congenital or early-acquired brain lesion, despite abundant generalized or bilateral epileptiform discharges on EEG, due to an interaction between the early lesion and the developing brain. Expand
Surgical pathologic findings of extratemporal-based intractable epilepsy: a study of 133 consecutive resections.
TLDR
It is demonstrated that most patients with extratemporal lobe epilepsy have significant histopathologic findings, which most frequently include cortical dysplasia, tumor, or evidence of remote ischemic damage or infarct. Expand
Abnormalities of gyration, heterotopias, tuberous sclerosis, focal cortical dysplasia, microdysgenesis, dysembryoplastic neuroepithelial tumour and dysgenesis of the archicortex in epilepsy. Clinical, EEG and neuroimaging features in 100 adult patients.
TLDR
There was poor correlation between the epileptic syndromes and EEG abnormalities and the location/extent of CD as defined by MRI and pathology. Expand
Surgery for Catastrophic Localization‐Related Epilepsy in Infants
Summary: Cortical resection or hemispherectomy has been reported to result in cessation or dramatic reduction of seizures for small numbers of highly selected infants with severe, intractableExpand
Life-threatening focal status epilepticus due to occult cortical dysplasia.
TLDR
Focal cortical dysplasia should be suspected when life-threatening focal motor status epilepticus or epilepsia partialis continua occur in children or young persons without another obvious cause, and normal magnetic resonance studies do not exclude neuronal migration disorders. Expand
Periventricular and subcortical nodular heterotopia. A study of 33 patients.
TLDR
Nodular heterotopias led to unilateral or bilateral independent temporal epileptic discharges in 47% of epileptic patients with PNH alone and in 61% of those who had SNH in addition. Expand
Pediatric epilepsy surgery in focal lesions and generalized electroencephalogram abnormalities.
TLDR
It is concluded that generalized and multiregional EEG abnormalities in the absence of dominant focus may not preclude epilepsy surgery in children with a congenital or acquired lesion seen on MRI. Expand
Surgical treatment of two patients with infantile spasms in early infancy
TLDR
Two patients who had infantile spasms and underwent surgery for epilepsy in early infancy and showed Engel classification I and catch-up developmental progress are reported. Expand
Clinical and Electroencephalographic Features of Infantile Spasms Associated with Malformations of Cortical Development
The aim of this study was to reveal the clinical and encephalographic (EEG) features of infantile spasms (IS) with malformations of cortical development (MCDs). The clinical features, EEG findings,Expand
...
1
2
3
...