Resection upregulates the IGF-I system of parenterally fed rats with jejunocolic anastomosis.

@article{Gillingham2001ResectionUT,
  title={Resection upregulates the IGF-I system of parenterally fed rats with jejunocolic anastomosis.},
  author={Melanie B. Gillingham and Karen R Kritsch and Sangita G. Murali and Pauline Kay Lund and Denise M Ney},
  journal={American journal of physiology. Gastrointestinal and liver physiology},
  year={2001},
  volume={281 5},
  pages={G1158-68}
}
Rats maintained with parenteral nutrition following 60% jejunoileal resection plus cecectomy exhibit minimal adaptive growth in the residual jejunum but a dramatic adaptive growth in the residual colon. Coinfusion of insulin-like growth factor I (IGF-I) with parenteral nutrition induces jejunal growth but has minimal effects in the colon. Our objective was to study the role of the endogenous IGF-I system in the differential responses of jejunum and colon to resection and/or IGF-I during… CONTINUE READING

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