Resection is responsible for loss of transcription around a double-strand break in Saccharomyces cerevisiae

@inproceedings{Manfrini2015ResectionIR,
  title={Resection is responsible for loss of transcription around a double-strand break in Saccharomyces cerevisiae},
  author={Nicola Manfrini and Michela Clerici and Maxime Wery and Chiara Vittoria Colombo and Marc Descrimes and Antonin Morillon and Fabrizio d'Adda di Fagagna and Maria Pia Longhese and Jessica K Tyler},
  booktitle={eLife},
  year={2015}
}
Emerging evidence indicate that the mammalian checkpoint kinase ATM induces transcriptional silencing in cis to DNA double-strand breaks (DSBs) through a poorly understood mechanism. Here we show that in Saccharomyces cerevisiae a single DSB causes transcriptional inhibition of proximal genes independently of Tel1/ATM and Mec1/ATR. Since the DSB ends undergo nucleolytic degradation (resection) of their 5'-ending strands, we investigated the contribution of resection in this DSB-induced… CONTINUE READING
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