Researchers turn off Down’s syndrome genes

@article{Mole2013ResearchersTO,
  title={Researchers turn off Down’s syndrome genes},
  author={Beth Marie Mole},
  journal={Nature},
  year={2013}
}
  • B. Mole
  • Published 17 July 2013
  • Biology
  • Nature
Silencing extra chromosome in cell cultures could lead to new treatments for the disorder. 
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References

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Translating Dosage Compensation to Trisomy 21
Down’s syndrome is a common disorder with enormous medical and social costs, caused by trisomy for chromosome 21. We tested the concept that gene imbalance across an extra chromosome can be de facto…
Trisomy correction in Down syndrome induced pluripotent stem cells.
TLDR
This study generated induced pluripotent stem cells from DS fibroblasts and introduced a TKNEO transgene into one copy of chromosome 21 by gene targeting and described a targeted removal of a human trisomy, which could prove useful in both clinical and research applications.