Research with animals: requirement, responsibility, welfare

  title={Research with animals: requirement, responsibility, welfare},
  author={O. Uvarov},
  journal={Laboratory Animals},
  pages={51 - 75}
  • O. Uvarov
  • Published 1985
  • Biology, Medicine
  • Laboratory Animals
Recognition of unacceptable cruelty to animals in pasttimes such as bull-baiting, dates in Britain from the early 19th century. The Society for the Prevention of Cruelty to Animals was founded in 1824. Several bills to curb cruelty were discussed in Parliament, and the Cruel and Improper Treatment of Cattle Act was passed in 1822. Other Acts have followed over the years. Cruelty in the form of painful scientific experiments, including dissection of living, conscious animals, vivisection, was… Expand
On the significance of animal experiments in toxinology.
  • J. Meier, K. Stocker
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By scoping on papers published in Toxicon between 1980 and 1986, the current situation of animal experimentation in toxinology is evaluated and the example of batroxobin, a purified serine proteinase from Bothrops moojeni venom used as a defibrinogenating agent is used. Expand
Responsibility and Laboratory Animal Research Governance
Analysis of the "Responsible Research and Innovation" agenda reveals RRI has the potential to helpfully augment the 3Rs in three key ways: recognizing the need to include a broader range of experts and publics in animal research governance; emphasizing the importance for animal research scientists of taking societal, and not just role, responsibilities into account; and acknowledging the political questions animal research raises. Expand
A refinement to the formalin test in mice
It is shown that anaesthetising the animal with the inhalable anaesthetic sevoflurane at the time of the injection can produce reliable, robust and reproducible results whilst animal distress during the initial phase is reduced. Expand
Solving an ethical issue involved in experimentation with animals in a brazilian teaching laboratory*
  • N. I. Loureiro, H. Viana, +5 authors H. Castro
  • Computer Science, Medicine
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  • 2004
An alternative experimental session to be conducted that eliminated the use of rats, the conventional in vivo model employed for learning metabolism of glycogen in the authors' university, and an alternative sample to simulate human urine, which is called guarurine is prepared. Expand
Amphibians as animal models for laboratory research in physiology.
Amphibians offer several advantages that include a well-understood basic physiology, a taxonomic diversity well suited to comparative studies, tolerance to temperature and oxygen variation, and a greater similarity to humans than many other currently popular animal models. Expand
Author(s): Thompson, Harry V. | Abstract: The relationships between man and other animals have attracted increased attention and some controversy in recent years. Their importance in biomedicalExpand
Adding RRI to the 3Rs: What Could Responsible Research and Innovation Offer Animal Research Governance
This article makes the case for incorporating dimensions of Responsible Research and Innovation (RRI) into the 3Rs principles (Replacement, Reduction and Refinement) and the governance of animalExpand
Animals used for Scientific Purposes
Those using conscious animals should apply to their studies such tenets as Russell and Burch's “3R” principle of reduction, replac ement and refinement; Dr Carol Newton's “3S” “principle of goodExpand
What are the validated animal models for tendinopathy?
It is concluded that established clinical, histopathological and functional characteristics of human tendinopathy were all important and relevant criteria to be met, if possible, by animal models. Expand
Description of the periodontal pocket in preclinical models: limitations and considerations
This review provides insight into the commonly used preclinical models for the reproduction of the periodontal pocket and discusses the advantages and disadvantages of each model in terms of similarity to human conditions, standardization and reproducibility. Expand


Editor's note to readers and authors on the ethics of animal experiments
Authors will be required to show that they have paid attention to the proposals of the Committee on Research and Ethical Issues which were published in Pain, 9 (1980) 141-144 from this time. Expand
Consideration of Provision and Characterization of Animal Models
The analysis of the present status of laboratory animal science indicates that the development of new experimental animals and disease models is necessary for the establishment of the principles and the methods of the extrapolation of animal data to humans. Expand
Of man and mouse.
This exercise has many different uses, for example, it can be used when you want to emphasize the reason why the authors need to have more than one person involved in a serious accident investigation, or the importance of different individuals conducting pre-start checks on equipment. Expand
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