Research review: dopamine transfer deficit: a neurobiological theory of altered reinforcement mechanisms in ADHD.

  title={Research review: dopamine transfer deficit: a neurobiological theory of altered reinforcement mechanisms in ADHD.},
  author={Gail Tripp and Jeffery R. Wickens},
  journal={Journal of child psychology and psychiatry, and allied disciplines},
  volume={49 7},
  • G. TrippJ. Wickens
  • Published 1 July 2008
  • Psychology, Biology
  • Journal of child psychology and psychiatry, and allied disciplines
This review considers the hypothesis that changes in dopamine signalling might account for altered sensitivity to positive reinforcement in children with ADHD. The existing evidence regarding dopamine cell activity in relation to positive reinforcement is reviewed. We focus on the anticipatory firing of dopamine cells brought about by a transfer of dopamine cell responses to cues that precede reinforcers. It is proposed that in children with ADHD there is diminished anticipatory dopamine cell… 

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