Research resource: the pdx1 cistrome of pancreatic islets.

  title={Research resource: the pdx1 cistrome of pancreatic islets.},
  author={Cynthia Khoo and Juxiang Yang and Samuel A Weinrott and Klaus H. Kaestner and Ali Naji and Jonathan Schug and Doris A. Stoffers},
  journal={Molecular endocrinology},
  volume={26 3},
The homeodomain transcription factor pancreas duodenal homeobox 1 (Pdx1, also known as insulin promoter factor 1) is a master regulator of pancreas development, as mice or humans lacking Pdx1 function are a pancreatic. Importantly, heterozygous mutations in Pdx1 cause early and late onset forms of diabetes in humans. Despite these central roles in development and adult β-cell function, we have only rudimentary knowledge of the transcriptome targets of Pdx1 that mediate these phenotypes… CONTINUE READING