• Psychology
  • Published 2000

Research report Antiepileptic efficacy of topiramate: assessment in two in vitro seizure

@inproceedings{Jahromi2000ResearchRA,
  title={Research report Antiepileptic efficacy of topiramate: assessment in two in vitro seizure},
  author={Shokrollah S. Jahromi and Marc R. Pelletier and Patrick McDonald and Houman Khosravani and Peter L. Carlen},
  year={2000}
}
The antiepileptic efficacy of topiramate (TPM) has been demonstrated in both whole animal seizure models and clinical trials; however, there is no consensus concerning its mechanism of action. We determined first whether the antiepileptic effect of TPM generalized to in vitro seizure models. Epileptiform discharges, recorded extracellularly, were evoked by repeated tetanic stimulation of Schaffer collaterals and layer III association fibers in entorhinal cortex / hippocampus and piriform cortex… CONTINUE READING