Research progresses of molecular mechanism of pyroptosis and its related diseases.

@article{Gong2019ResearchPO,
  title={Research progresses of molecular mechanism of pyroptosis and its related diseases.},
  author={Weihua Gong and Ying Shi and Jingjing Ren},
  journal={Immunobiology},
  year={2019}
}

THE MOLECULAR MECHANISM OF PYROPTOSIS AND ITS RELATED DISEASES

Inflammasomes and cytokines produced in the process of pyroptosis can trigger an inflammatory response in the body, and an excessive inflammatory response can lead to diseases, such as infectious diseases, neurological diseases, and tumors.

Pyroptosis and Its Role in the Modulation of Cancer Progression and Antitumor Immunity

With the progression in the field of pyroptosis, new therapeutic targets and strategies can be explored to combat cancer.

Pyroptosis in inflammatory diseases and cancer

This review focuses on the recent progress in strategies that inhibit pyroptosis for treatment of inflammatory diseases, and those that induce pyroaptosis for cancer therapy and should shed light on future directions and provide novel ideas for using pyroPTosis as a powerful tool to fight inflammatory diseases and cancer.

Emerging Role of the Inflammasome and Pyroptosis in Hypertension

The recent literature addressing the role of pyroptosis and the inflammasome in the development of hypertension is summarized and the potential use of approaches targeting this pathway as future anti-hypertensive strategies are discussed.

Inflammasome and Inflammatory Programmed Cell Death in Chromoblastomycosis.

The intense presence of caspase 1, IL1β and IL18, allied to NLRP1 expression, suggest that inflammasome and pyroptosis could play a role in the immune response against fungal agents of CBM.

PP1A prevents ROS‐induced pyroptosis by inhibiting MAPK/caspase‐3 in mouse adipose tissue

It is demonstrated that PP1A suppressed pyroptosis in adipocytes by inhibiting the reactive oxygen species/mitogen‐activated protein kinase/caspase‐3 signaling pathway and promoting M2 macrophage polarization.

Inflammasomes and Colorectal Cancer

This work reviews extant studies delving into different functions of inflammasomes in colorectal cancer development and concludes that infammasomes play contradictory roles in the development of inflammation-induced cancers.

Research Progress on the Role of Pyroptosis in Myocardial Ischemia-Reperfusion Injury

This review describes the pyroptosis mechanism in MIRI and its relationship with other mechanisms, and also highlights non-coding RNAs and non-cardiomyocytes as regulators of cardiomyocyte pyroPTosis by mediating associated pathways or proteins to participate in the initiation and development of M IRI.

Isoorientin Attenuated the Pyroptotic Hepatocyte Damage Induced by Benzo[a]pyrene via ROS/NF-κB/NLRP3/Caspase-1 Signaling Pathway

Iso could alleviate the BaP-induced pyroptotic hepatocytes injury through inhibiting the ROS/NF-κB/NLRP3/Caspase-1 signaling pathway, which provides a new perspective and strategy to prevent liver injury induced by BaP.

References

SHOWING 1-10 OF 50 REFERENCES

Gasdermins: Effectors of Pyroptosis.

Gasdermins pore cell membrane to pyroptosis

To understand the mechanism of pore formation during pyroptosis process, immunologists studied the substrates and downstream signaling pathways of activated inflammatory caspases.

The Role of Cell Death in the Pathogenesis of SLE: Is Pyroptosis the Missing Link?

While the role of pyroptosis in SLE is hypothetical at this time, further analysis of this death form should provide new insights into lupus pathogenesis and provide the missing link between infection and the initiation of l upus by products of dead and dying cells.

Pyroptotic cell death defends against intracellular pathogens

This review focuses on molecular and morphological characteristics of pyroptosis and the individual inflammasomes and their contribution to defense against infection in mice and humans.

GSDMD membrane pore formation constitutes the mechanism of pyroptotic cell death

Overall, these data demonstrate that GSDMD is the direct and final executor of pyroptotic cell death.

Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores

It is shown that GSDMD-NT oligomerizes in membranes to form pores that are visible by electron microscopy and kills cell-free bacteria in vitro and may have a direct bactericidal effect within the cytosol of host cells, but the importance of direct bacterial killing in controlling in vivo infection remains to be determined.

Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death

Gasdermin D (Gsdmd) is identified by genome-wide clustered regularly interspaced palindromic repeat-Cas9 nuclease screens of caspase-11- and caspasing-1-mediated pyroptosis in mouse bone marrow macrophages to offer insight into inflammasome-mediated immunity/diseases and change the understanding of pyroPTosis and programmed necrosis.

Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling

It is shown that gasdermin D is essential for caspase-11-dependent pyroptosis and interleukin-1β maturation and a key mediator of the host response against Gram-negative bacteria.