Research progress on neurobiology of neuronal nitric oxide synthase

  title={Research progress on neurobiology of neuronal nitric oxide synthase},
  author={Chun-Xia Luo 罗春霞 and Dong-Ya Zhu 朱东亚},
  journal={Neuroscience Bulletin},
Neuronal nitric oxide synthase (nNOS) is mainly expressed in neurons, to some extent in astrocytes and neuronal stem cells. The alternative splicing of nNOS mRNA generates 5 isoforms of nNOS, including nNOS-α, nNOS-β, nNOS-μ, nNOS-γ and nNOS-2. Monomer of nNOS is inactive, and dimer is the active form. Dimerization requires tetrahydrobiopterin (BH4), heme and L-arginine binding. Regulation of nNOS expression relies largely on cAMP response element-binding protein (CREB) activity, and nNOS… CONTINUE READING


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