Research progress on neurobiology of neuronal nitric oxide synthase

@article{2011ResearchPO,
  title={Research progress on neurobiology of neuronal nitric oxide synthase},
  author={Chun-Xia Luo 罗春霞 and Dong-Ya Zhu 朱东亚},
  journal={Neuroscience Bulletin},
  year={2011},
  volume={27},
  pages={23-35}
}
Neuronal nitric oxide synthase (nNOS) is mainly expressed in neurons, to some extent in astrocytes and neuronal stem cells. The alternative splicing of nNOS mRNA generates 5 isoforms of nNOS, including nNOS-α, nNOS-β, nNOS-μ, nNOS-γ and nNOS-2. Monomer of nNOS is inactive, and dimer is the active form. Dimerization requires tetrahydrobiopterin (BH4), heme and L-arginine binding. Regulation of nNOS expression relies largely on cAMP response element-binding protein (CREB) activity, and nNOS… CONTINUE READING

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References

Publications referenced by this paper.
Showing 1-10 of 131 references

NOS1AP associates with Scribble and regulates dendritic spine development.

The Journal of neuroscience : the official journal of the Society for Neuroscience • 2010
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