Research on psychoneuroimmunology: does stress influence immunity and cause coronary artery disease?

  title={Research on psychoneuroimmunology: does stress influence immunity and cause coronary artery disease?},
  author={Roger Chun-Man Ho and Li Fang Neo and Anna N C Chua and Alicia Ai-cia Cheak and Anselm Mak},
  journal={Annals of the Academy of Medicine, Singapore},
  volume={39 3},
  • R. HoL. F. Neo A. Mak
  • Published 1 March 2010
  • Psychology, Medicine
  • Annals of the Academy of Medicine, Singapore
This review addresses the importance of psychoneuroimmunology (PNI) studies in understanding the role of acute and chronic psychological stressors on the immune system and development of coronary artery disease (CAD). Firstly, it illustrates how psychological stressors change endothelial function and lead to chemotaxis. Secondly, acute psychological stressors lead to leukocytosis, increased natural killer cell cytotoxicity and reduced proliferative response to mitogens while chronic… 

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