Research on antioxidant effects and estrogenic effect of formononetin from Trifolium pratense (red clover).

Abstract

Antioxidant and estrogenic effects of formononetin on ovariectomized mice have been investigated in the present study. The adult female Kunming mice were divided into 5 groups: sham-operated group, ovariectomized group, stilbestrol replacement therapy group (0.20 mg/kg day), low-dose formononetin group (0.05 g/kg day) and high-dose formononetin group (0.5 g/kg day). The mice in the latter 4 groups were ovariectomized. The drug was given by oral administration for 6 months. Estrogenic effect was determined by the change of uterine weight, and oxidant effects were determined by the content of SOD, GSH-Px, CAT and MDA. The intake of formononetin increased the uterine weight of the mice significantly as well as the content of SOD, GSH-Px, CAT, and reduced MDA in body. Formononetin had obvious antioxidant effects and estrogenic effect, and the estrogenic effect was not dosage-related.

DOI: 10.1016/j.phymed.2008.07.005
020040020102011201220132014201520162017
Citations per Year

912 Citations

Semantic Scholar estimates that this publication has 912 citations based on the available data.

See our FAQ for additional information.

Cite this paper

@article{Mu2009ResearchOA, title={Research on antioxidant effects and estrogenic effect of formononetin from Trifolium pratense (red clover).}, author={Hiroshi Mu and Y-H Bai and S Wang and Z-M Zhu and Ye-wei Zhang}, journal={Phytomedicine : international journal of phytotherapy and phytopharmacology}, year={2009}, volume={16 4}, pages={314-9} }