Myopia is a public health problem in the world and its prevalence and incidence are rising in recent years. Studies have shown that myopia is a kind of complex genetic diseases. And sclera-remodeling plays an important role in the development of myopia. The recent research advances in association with both sclera-remodeling relevant gene polymorphisms and myopia are reviewed in this article. (Chin J Ophthalmol, 2016, 52: 876-880).