Rescuing effects of RXR agonist bexarotene on aging-related synapse loss depend on neuronal LRP1.


Apolipoprotein E (apoE) plays a critical role in maintaining synaptic integrity by transporting cholesterol to neurons through the low-density lipoprotein receptor related protein-1 (LRP1). Bexarotene, a retinoid X receptor (RXR) agonist, has been reported to have potential beneficial effects on cognition by increasing brain apoE levels and lipidation. To… (More)
DOI: 10.1016/j.expneurol.2015.12.003


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