Rescuing cocaine-induced prefrontal cortex hypoactivity prevents compulsive cocaine seeking

@article{Chen2013RescuingCP,
  title={Rescuing cocaine-induced prefrontal cortex hypoactivity prevents compulsive cocaine seeking},
  author={Billy T. Chen and Hau-Jie Yau and Christina E. Hatch and Ikue Kusumoto-Yoshida and Saemi L. Cho and Frederic Woodward Hopf and Antonello Bonci},
  journal={Nature},
  year={2013},
  volume={496},
  pages={359-362}
}
Loss of control over harmful drug seeking is one of the most intractable aspects of addiction, as human substance abusers continue to pursue drugs despite incurring significant negative consequences. [] Key Method Here we use a rat model of compulsive drug seeking in which cocaine seeking persists in a subgroup of rats despite delivery of noxious foot shocks. We show that prolonged cocaine self-administration decreases ex vivo intrinsic excitability of deep-layer pyramidal neurons in the prelimbic cortex…

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