Rescuing cocaine-induced prefrontal cortex hypoactivity prevents compulsive cocaine seeking

  title={Rescuing cocaine-induced prefrontal cortex hypoactivity prevents compulsive cocaine seeking},
  author={Billy T. Chen and Hau-Jie Yau and Christina E. Hatch and Ikue Kusumoto-Yoshida and Saemi L. Cho and Frederic Woodward Hopf and Antonello Bonci},
Loss of control over harmful drug seeking is one of the most intractable aspects of addiction, as human substance abusers continue to pursue drugs despite incurring significant negative consequences. [] Key Method Here we use a rat model of compulsive drug seeking in which cocaine seeking persists in a subgroup of rats despite delivery of noxious foot shocks. We show that prolonged cocaine self-administration decreases ex vivo intrinsic excitability of deep-layer pyramidal neurons in the prelimbic cortex…

Behavioral and neural mechanisms underlying habitual and compulsive drug seeking

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Compulsive drug seeking by rats under punishment: effects of drug taking history

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