Rescuing chemotaxis of the anticancer agent Salmonella enterica serovar Typhimurium VNP20009.

@article{Broadway2015RescuingCO,
  title={Rescuing chemotaxis of the anticancer agent Salmonella enterica serovar Typhimurium VNP20009.},
  author={Katherine M. Broadway and Elizabeth A P Denson and Roderick V. Jensen and Birgit E. Scharf},
  journal={Journal of biotechnology},
  year={2015},
  volume={211},
  pages={117-20}
}
The role of chemotaxis and motility in Salmonella enterica serovar Typhimurium tumor colonization remains unclear. We determined through swim plate assays that the well-established anticancer agent S. Typhimurium VNP20009 is deficient in chemotaxis, and that this phenotype is suppressible. Through genome sequencing, we revealed that VNP20009 and four selected suppressor mutants had a single nucleotide polymorphism (SNP) in cheY causing a mutation in the conserved proline residue at position 110… CONTINUE READING