Rescue therapies for seizure clusters: Pharmacology and target of treatments

@article{Gidal2022RescueTF,
  title={Rescue therapies for seizure clusters: Pharmacology and target of treatments},
  author={Barry E. Gidal and Kamil Detyniecki},
  journal={Epilepsia},
  year={2022},
  volume={63},
  pages={S34 - S44}
}
The primary goal of treatment for seizure clusters is cessation of the cluster to avoid progression to more severe conditions, such as prolonged seizures and status epilepticus. Rescue therapies are key components of treatment plans for patients with seizure clusters. Three rescue therapies are approved in the United States for the treatment of seizure clusters: diazepam rectal gel, midazolam nasal spray, and diazepam nasal spray. This review characterizes the pharmacological function of rescue… 

Consequences: Bench to home

Clinicians can affect patient quality of life and clinical outcomes through improved seizure cluster education and treatment, such as the development and implementation of a personalized seizure action plan as well as prescriptions for suitable rescue medications indicated for seizure clusters and instructions for their proper use.

Future opportunities for research in rescue treatments

By focusing on novel end points and technologies with value to patients, caregivers, and clinicians, data obtained from future studies can benefit the diverse patient population that experiences seizure clusters, providing more effective, appropriate care as well as alleviating demands on health care resources.

Introduction to use of an acute seizure action plan for seizure clusters and guidance for implementation

This work examines the current usage and value of SAPs for pediatric and adult patients with epilepsy, and introduces the concept of the acute SAP (ASAP) for use specifically during seizure emergencies, such as seizure clusters.

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Consequences: Bench to home

Clinicians can affect patient quality of life and clinical outcomes through improved seizure cluster education and treatment, such as the development and implementation of a personalized seizure action plan as well as prescriptions for suitable rescue medications indicated for seizure clusters and instructions for their proper use.

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Introduction to use of an acute seizure action plan for seizure clusters and guidance for implementation

This work examines the current usage and value of SAPs for pediatric and adult patients with epilepsy, and introduces the concept of the acute SAP (ASAP) for use specifically during seizure emergencies, such as seizure clusters.

Subunit-Specific Trafficking of GABAA Receptors during Status Epilepticus

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