Rescue of the T-associated maternal effect in mice carrying null mutations in Igf-2 and Igf2r, two reciprocally imprinted genes.

@article{Filson1993RescueOT,
  title={Rescue of the T-associated maternal effect in mice carrying null mutations in Igf-2 and Igf2r, two reciprocally imprinted genes.},
  author={Adele J Filson and Angeliki Louvi and A. Efstratiadis and Elisabeth J Robertson},
  journal={Development},
  year={1993},
  volume={118 3},
  pages={731-6}
}
In mice, only the paternal allele of the Igf2 gene, encoding insulin-like growth factor II (IGF-II) is expressed due to parental imprinting. Interestingly, the Igf2r gene, which encodes one of the two known receptors (IGF2R) to which IGF-II binds with high affinity is also subject to imprinting, but in a reciprocal fashion. This observation raises the possibility that imprinting of these loci serves to regulate the ratios of the gene products, since IGF2R provides a mechanism for IGF-II… CONTINUE READING
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Insulin - like growth factor receptors

  • C. Moxham, S. Jacobs
  • The Insulin - like Growth Factors : Structure and…
  • 1992

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