Rescue of the HNF4 --> HNF1alpha pathway in hepatoma variant cells containing human chromosome 12.

@article{Bulla1998RescueOT,
  title={Rescue of the HNF4 --> HNF1alpha pathway in hepatoma variant cells containing human chromosome 12.},
  author={Gary A. Bulla and Jacqueline R. Batanian and Heather M. Young and Nicolette Bradley and Navaid Kazi and Bassem R. Haddad},
  journal={Genomics},
  year={1998},
  volume={54 3},
  pages={398-407}
}
Expression of liver-enriched trans-acting hepatocyte nuclear factors 1alpha (HNF1alpha) and 4 (HNF4) is correlated with the hepatic phenotype in cultured rat hepatoma cells. We have used a hepatoma variant cell line, H11, that specifically lacks the HNF4 --> HNF1alpha pathway as a model to understand mechanisms controlling hepatic gene expression. We have… CONTINUE READING