Rescue of the En-1 mutant phenotype by replacement of En-1 with En-2.

@article{Hanks1995RescueOT,
  title={Rescue of the En-1 mutant phenotype by replacement of En-1 with En-2.},
  author={Mark C. Hanks and Wolfgang Wurst and Lynn C Anson-Cartwright and Anna B. Auerbach and Alexandra L. Joyner},
  journal={Science},
  year={1995},
  volume={269 5224},
  pages={679-82}
}
The related mouse Engrailed genes En-1 and En-2 are expressed from the one- and approximately five-somite stages, respectively, in a similar presumptive mid-hindbrain domain. However, mutations in En-1 and En-2 produce different phenotypes. En-1 mutant mice die at birth with a large mid-hindbrain deletion, whereas En-2 mutants are viable, with cerebellar defects. To determine whether these contrasting phenotypes reflect differences in temporal expression or biochemical activity of the En… CONTINUE READING
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