Rescue of odontogenesis in Dmp1-deficient mice by targeted re-expression of DMP1 reveals roles for DMP1 in early odontogenesis and dentin apposition in vivo.

@article{Lu2007RescueOO,
  title={Rescue of odontogenesis in Dmp1-deficient mice by targeted re-expression of DMP1 reveals roles for DMP1 in early odontogenesis and dentin apposition in vivo.},
  author={Yongbo Lu and L Ye and S Michael Yu and Shubin Zhang and Yixia Xie and Marc D McKee and Yan Li and Juan Kong and J. David Eick and Sarah L Dallas and Jian Feng},
  journal={Developmental biology},
  year={2007},
  volume={303 1},
  pages={
          191-201
        }
}
Dentin matrix protein 1 (DMP1) is expressed in both pulp and odontoblast cells and deletion of the Dmp1 gene leads to defects in odontogenesis and mineralization. The goals of this study were to examine how DMP1 controls dentin mineralization and odontogenesis in vivo. Fluorochrome labeling of dentin in Dmp1-null mice showed a diffuse labeling pattern with a 3-fold reduction in dentin appositional rate compared to controls. Deletion of DMP1 was also associated with abnormalities in the dentinal… CONTINUE READING
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