Rescue of obesity-induced infertility in female mice due to a pituitary-specific knockout of the insulin receptor.

@article{Brothers2010RescueOO,
  title={Rescue of obesity-induced infertility in female mice due to a pituitary-specific knockout of the insulin receptor.},
  author={Kathryn J Brothers and Sheng Wu and Sara A Divall and Marcus R Messmer and C Ronald Kahn and Ryan S Miller and Sally Radovick and Fredric E. Wondisford and Andrew Wolfe},
  journal={Cell metabolism},
  year={2010},
  volume={12 3},
  pages={295-305}
}
Obesity is associated with insulin resistance in metabolic tissues such as adipose, liver, and muscle, but it is unclear whether nonclassical target tissues, such as those of the reproductive axis, are also insulin resistant. To determine if the reproductive axis maintains insulin sensitivity in obesity in vivo, murine models of diet-induced obesity (DIO) with and without intact insulin signaling in pituitary gonadotrophs were created. Diet-induced obese wild-type female mice (WT DIO) were… CONTINUE READING
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