Rescue of non-sense mutated p53 tumor suppressor gene by aminoglycosides

@inproceedings{Floquet2011RescueON,
  title={Rescue of non-sense mutated p53 tumor suppressor gene by aminoglycosides},
  author={C{\'e}lia Floquet and Jules Deforges and Jean-Pierre Rousset and Laure Bidou},
  booktitle={Nucleic acids research},
  year={2011}
}
Mutation-based treatments are a new development in genetic medicine, in which the nature of the mutation dictates the therapeutic strategy. Interest has recently focused on diseases caused by premature termination codons (PTCs). Drugs inducing the readthrough of these PTCs restore the production of a full-length protein. In this study, we explored the possibility of using aminoglycoside antibiotics to induce the production of a full-length functional p53 protein from a gene carrying a PTC. We… CONTINUE READING
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