Rescue of impaired fracture healing in COX-2-/- mice via activation of prostaglandin E2 receptor subtype 4.

@article{Xie2009RescueOI,
  title={Rescue of impaired fracture healing in COX-2-/- mice via activation of prostaglandin E2 receptor subtype 4.},
  author={Chao Xie and Bojian Liang and Ming Xue and Angela S. P. Lin and Alayna E Loiselle and Edward M Schwarz and Robert Erling Guldberg and Regis J O'keefe and Xinping Zhang},
  journal={The American journal of pathology},
  year={2009},
  volume={175 2},
  pages={772-85}
}
Although the essential role of cyclooxygenase (COX)-2 in fracture healing is known, the targeted genes and molecular pathways remain unclear. Using prostaglandin E2 receptor (EP)2 and EP4 agonists, we examined the effects of EP receptor activation in compensation for the lack of COX-2 during fracture healing. In a fracture-healing model, COX-2(-/-) mice showed delayed initiation and impaired endochondral bone repair, accompanied by a severe angiogenesis deficiency. The EP4 agonist markedly… CONTINUE READING
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