Rescue of developing spinal motoneurons from programmed cell death by the GABA(A) agonist muscimol acts by blockade of neuromuscular activity and increased intramuscular nerve branching.

@article{Oppenheim2003RescueOD,
  title={Rescue of developing spinal motoneurons from programmed cell death by the GABA(A) agonist muscimol acts by blockade of neuromuscular activity and increased intramuscular nerve branching.},
  author={Ronald W. Oppenheim and Jordi Calder{\'o} and Dolors Cuitat and Josep E. Esquerda and Vict{\`o}ria Ayala and David M. Prevette and Siwei Wang},
  journal={Molecular and cellular neurosciences},
  year={2003},
  volume={22 3},
  pages={331-43}
}
Blockade of neuromuscular activity in the chick embryo during the period of programmed cell death of motoneurons results in a complete rescue of these cells. Understanding the cellular mechanisms that mediate this counterintuitive effect is of considerable interest with respect to the regulation of motoneuron survival during development as well as for understanding why motoneurons die pathologically. Although considerable evidence supports the role of a peripheral site of action at the… CONTINUE READING
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