Rescue of cardiomyopathy in peroxisome proliferator-activated receptor-alpha transgenic mice by deletion of lipoprotein lipase identifies sources of cardiac lipids and peroxisome proliferator-activated receptor-alpha activators.

@article{Duncan2010RescueOC,
  title={Rescue of cardiomyopathy in peroxisome proliferator-activated receptor-alpha transgenic mice by deletion of lipoprotein lipase identifies sources of cardiac lipids and peroxisome proliferator-activated receptor-alpha activators.},
  author={Jennifer G. Duncan and Kalyani G Bharadwaj and J. -C. Li Sui Fong and Riddhi Mitra and Nandakumar Sambandam and Michael R Courtois and Kory J. Lavine and Ira J Goldberg and D. P. Kelly},
  journal={Circulation},
  year={2010},
  volume={121 3},
  pages={426-35}
}
BACKGROUND Emerging evidence in obesity and diabetes mellitus demonstrates that excessive myocardial fatty acid uptake and oxidation contribute to cardiac dysfunction. Transgenic mice with cardiac-specific overexpression of the fatty acid-activated nuclear receptor peroxisome proliferator-activated receptor-alpha (myosin heavy chain [MHC]-PPARalpha mice) exhibit phenotypic features of the diabetic heart, which are rescued by deletion of CD36, a fatty acid transporter, despite persistent… CONTINUE READING