Rescue of amitriptyline-intoxicated hearts with nanosized vesicles.

  title={Rescue of amitriptyline-intoxicated hearts with nanosized vesicles.},
  author={Anand Babu Dhanikula and Daniel Lamontagne and Jean-Christophe Leroux},
  journal={Cardiovascular research},
  volume={74 3},
OBJECTIVE Amitriptyline, one of the most prescribed antidepressants, is reported to claim a large number of human lives due to drug overdose related cardiac arrest. Although amitriptyline poisoning has long been recognized as a frequent and serious fatality in the medical field, few efforts have been made to devise methods for treating its toxicity. To address this issue, phospholipid-based nanosized vesicles (spherulites) were employed to reverse the cardiotoxicity induced by amitriptyline in… CONTINUE READING


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