Rescue of alpha-SNS sodium channel expression in small dorsal root ganglion neurons after axotomy by nerve growth factor in vivo.

@article{DibHajj1998RescueOA,
  title={Rescue of alpha-SNS sodium channel expression in small dorsal root ganglion neurons after axotomy by nerve growth factor in vivo.},
  author={Sulayman D. Dib-Hajj and J Andrew Black and Theodore R. Cummins and Arthur Kenney and Jeffery D Kocsis and Stephen G. Waxman},
  journal={Journal of neurophysiology},
  year={1998},
  volume={79 5},
  pages={2668-76}
}
Small (18-25 microm diam) dorsal root ganglion (DRG) neurons are known to express high levels of tetrodotoxin-resistant (TTX-R) sodium current and the mRNA for the alpha-SNS sodium channel, which encodes a TTX-R channel when expressed in oocytes. These neurons also preferentially express the high affinity receptor for nerve growth factor (NGF), TrkA. Levels of TTX-R sodium current and of alpha-SNS mRNA are reduced in these cells after axotomy. To determine whether NGF participates in the… CONTINUE READING
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