Rescue of aging-associated decline in Dnmt3a2 expression restores cognitive abilities

  title={Rescue of aging-associated decline in Dnmt3a2 expression restores cognitive abilities},
  author={Ana M. M. Oliveira and Thekla J Hemstedt and Hilmar Bading},
  journal={Nature Neuroscience},
Cognitive abilities decline in normal aging, yet the underlying molecular mechanisms are poorly understood. We found that aging was associated with a decrease in the expression of the DNA methyltransferase Dnmt3a2 in the hippocampus and that rescuing Dnmt3a2 levels restored cognitive functions. Moreover, we found that Dnmt3a2 is an activity-regulated immediate early gene that is partly dependent on nuclear calcium signaling and that hippocampal Dnmt3a2 levels determine cognitive abilities in… 

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