Rescue of a trafficking defective human pacemaker channel via a novel mechanism: roles of Src, Fyn, and Yes tyrosine kinases.

@article{Lin2009RescueOA,
  title={Rescue of a trafficking defective human pacemaker channel via a novel mechanism: roles of Src, Fyn, and Yes tyrosine kinases.},
  author={Yen-Chang Lin and Jianying Huang and Hong Kan and Jefferson C Frisbee and Han-Gang Yu},
  journal={The Journal of biological chemistry},
  year={2009},
  volume={284 44},
  pages={30433-40}
}
Therapeutic strategies such as using channel blockers and reducing culture temperature have been used to rescue some long QT-associated voltage-gated potassium Kv trafficking defective mutant channels. A hyperpolarization-activated cyclic nucleotide-gated HCN4 pacemaker channel mutant (D553N) has been recently found in a patient associated with cardiac… CONTINUE READING