Rescue of a lethal T/t locus genotype by chimaerism with normal embryos

@article{Bennett1978RescueOA,
  title={Rescue of a lethal T/t locus genotype by chimaerism with normal embryos},
  author={Dorothea Bennett},
  journal={Nature},
  year={1978},
  volume={272},
  pages={539-539}
}
THE mutation THp at the T/t locus in the mouse is unique among mammalian genes because it has a sharply defined maternal effect. Like other known T/t locus dominant mutations, THp yields a short-tailed phenotype in heterozygotes of both sexes. However, THp/+ females when mated with wild type fail to give birth to short–tailed progeny; examination of embryos… CONTINUE READING