Rescue of a Drosophila NF1 mutant phenotype by protein kinase A.

  title={Rescue of a Drosophila NF1 mutant phenotype by protein kinase A.},
  author={Inge The and Gregory Edward Hannigan and Glenn S Cowley and S Reginald and Yi Zhong and James F. Gusella and Iswar K Hariharan and Andre Bernards},
  volume={276 5313},
The neurofibromatosis type 1 (NF1) tumor suppressor protein is thought to restrict cell proliferation by functioning as a Ras-specific guanosine triphosphatase-activating protein. However, Drosophila homozygous for null mutations of an NF1 homolog showed no obvious signs of perturbed Ras1-mediated signaling. Loss of NF1 resulted in a reduction in size of larvae, pupae, and adults. This size defect was not modified by manipulating Ras1 signaling but was restored by expression of activated… CONTINUE READING
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