Rescue of SCID murine ischemic hindlimbs with pH-modified rhbFGF/poly(DL-lactic-co-glycolic acid) implants.

@article{Zhong2007RescueOS,
  title={Rescue of SCID murine ischemic hindlimbs with pH-modified rhbFGF/poly(DL-lactic-co-glycolic acid) implants.},
  author={Yanqiang Zhong and Li Zhang and Amy G. Ding and Anna Shenderova and Gaozhong Zhu and P. T. Pei and Ruth R. Chen and Susan R. Mallery and David J Mooney and Steven P Schwendeman},
  journal={Journal of controlled release : official journal of the Controlled Release Society},
  year={2007},
  volume={122 3},
  pages={331-7}
}
Site-specific controlled release of biologically active angiogenic growth factors such as recombinant human basic fibroblast growth factor (rhbFGF) is a promising approach to improve collateral circulation in patients suffering from ischemic heart disease or peripheral vascular disease. Previously, we demonstrated stabilization of rhbFGF encapsulated in injectable poly(DL-lactic-co-glycolic acid) (PLGA) millicylindrical implants upon co-incorporation of Mg(OH)2 to raise the microclimate pH in… CONTINUE READING
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