Rescue of Recombinant Marburg Virus from cDNA Is Dependent on Nucleocapsid Protein VP30

@article{Enterlein2006RescueOR,
  title={Rescue of Recombinant Marburg Virus from cDNA Is Dependent on Nucleocapsid Protein VP30},
  author={Sven Enterlein and Viktor E. Volchkov and Michael Weik and Larissa Kolesnikova and Valentina A. Volchkova and Hans Dieter Klenk and Elke M{\"u}hlberger},
  journal={Journal of Virology},
  year={2006},
  volume={80},
  pages={1038 - 1043}
}
ABSTRACT Here we report recovery of infectious Marburg virus (MARV) from a full-length cDNA clone. Compared to the wild-type virus, recombinant MARV showed no difference in terms of morphology of virus particles, intracellular distribution in infected cells, and growth kinetics. The nucleocapsid protein VP30 of MARV and Ebola virus (EBOV) contains a Zn-binding motif which is important for the function of VP30 as a transcriptional activator in EBOV, whereas its role for MARV is unclear. It has… 
Phosphorylated VP30 of Marburg Virus Is a Repressor of Transcription
The largest outbreak of MARV occurred in Angola in 2004 to 2005 and had a 90% case fatality rate. There are no approved treatments available for MARV. Development of antivirals as therapeutics
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TLDR
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