Rescue of ATXN 3 neuronal toxicity in C . elegans by chemical modification of ER stress

Abstract

Background: Polyglutamine expansion diseases are a group of hereditary neurodegenerative disorders that develop when a CAG repeat in the causative genes are unstably expanded above a certain threshold. The expansion of trinucleotide CAG repeats cause hereditary adult-onset neurodegenerative disorders such as Huntington’s disease, dentatorubral… (More)

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